Triple Positive Breast Cancer
A Unique Treatment Landscape
Triple Positive Breast Cancer is a subtype of breast cancer that tests positive for all three main markers: estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2). This unique combination of receptors influences the growth and spread of the cancer cells and has important implications for treatment options and outcomes.
Characteristics of Triple Positive Breast Cancer Triple Positive Breast Cancer has several distinct features:
- Presence of ER, PR, and HER2 receptors, which can be targeted by specific therapies
- Tends to be more aggressive than hormone receptor-positive, HER2-negative breast cancers
- Higher risk of recurrence compared to hormone receptor-positive, HER2-negative breast cancers
- Responds well to a combination of hormone therapy, HER2-targeted therapy, and chemotherapy
Symptoms of Triple Positive Breast Cancer are similar to other types of breast cancer and may include a lump or mass in the breast, changes in breast size or shape, skin dimpling or irritation, and nipple changes or discharge.
Diagnosis and Treatment
Diagnosing Triple Positive Breast Cancer involves a biopsy to determine the presence of ER, PR, and HER2 receptors. This is done through specialized tests, such as immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH).
Treatment for Triple Positive Breast Cancer typically involves a combination of therapies, including:
- Hormone therapy, such as tamoxifen or aromatase inhibitors, to block the effects of estrogen on the cancer cells
- HER2-targeted therapies, such as trastuzumab (Herceptin), pertuzumab (Perjeta), and ado-trastuzumab emtansine (Kadcyla), to specifically target the HER2 protein
- Chemotherapy, often given in combination with hormone therapy and HER2-targeted therapies
- Surgery, such as lumpectomy or mastectomy, to remove the tumor and surrounding tissue
- Radiation therapy to reduce the risk of local recurrence after lumpectomy
The availability of multiple targeted therapies has improved outcomes for patients with Triple Positive Breast Cancer, allowing for personalized treatment plans that address the unique characteristics of each individual’s cancer.
Survivor Spotlight:
Erin, USA
“On March 26, I would receive the news that I had Invasive Ductal Carcinoma breast cancer (stage 2b) and in early April 2019, I’d start marathon treatment journey with Triple Positive (HR+/PR+/HER2+) breast cancer.”
Erin’s story highlights the complex treatment journey that often accompanies a Triple Positive Breast Cancer diagnosis. Her determination to navigate the “marathon” of treatment serves as an inspiration for others facing this unique subtype of breast cancer.
Thriving with Triple Positive Breast Cancer: Support and Self-Care
A diagnosis of Triple Positive Breast Cancer can be overwhelming, and it’s crucial for individuals to have access to comprehensive support services, including:
- Emotional support through counseling, support groups, and peer mentoring
- Educational resources to understand the unique aspects of Triple Positive Breast Cancer and its treatment options
- Assistance with managing side effects, such as fatigue, nausea, and peripheral neuropathy
- Survivorship care to address long-term physical and emotional needs after treatment
Self-care and self-advocacy are also essential for those living with Triple Positive Breast Cancer. This may involve prioritizing physical and emotional well-being, seeking second opinions, and openly communicating with healthcare providers about concerns and preferences.
At Learn Look Locate, we are dedicated to providing up-to-date information and resources to support and empower individuals affected by Triple Positive Breast Cancer. By raising awareness, promoting research, and sharing survivor stories, we aim to foster a community of hope and resilience.
Remember, if you or a loved one is facing Triple Positive Breast Cancer, you are not alone. With targeted therapies, a personalized approach to care, and a strong support network, many individuals are living full, vibrant lives with this subtype of breast cancer. Stay informed, prioritize your well-being, and draw upon the collective strength and wisdom of the Triple Positive Breast Cancer community as you navigate your unique journey.
