Increased Survival Rates by Charles Weaver

Kisqali prolongs survival for Pre-menopausal ER positive HER2 Neg breast cancer. San Antonio 2022

The US Food and Drug Administration approved the precision cancer medicine Kisqali® (ribociclib, LEE011) for first line treatment of estrogen hormone receptor positive (ER+), HER 2 negative (HER2-Neg) metastatic breast cancer because when combined with other hormonal therapy the combination benefits all such women and leads to improved survival without cancer recurrence compared to chemotherapy or other standard hormone therapies.

Advanced or metastatic breast cancer refers to cancer that originated in the breast, but has spread to several and/or distant sites in the body. The goals of treatment for metastatic breast cancer are to improve duration of survival while maintaining quality of life.

The majority of breast cancers are referred to as HR+, meaning their cancer is stimulated to grow from exposure to the female hormones estrogen and/or progesterone. These patients are often treated with endocrine therapy (sometimes referred to as hormone, or anti-estrogen therapy), which reduces the cancer cells’ exposure to estrogen through varying mechanisms. Endocrine therapy has proven extremely effective in reducing HR-positive cancer growth and spread for extended periods of time.

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