Breast Cancer, Heart Disease, and Your Life

In the United States today, there are over 3.8 million women who have survived breast cancer. Fortunately, thanks to improvements in treatments and the way we prevent cancer, the number is increasing as well. But, a new study has shown that many of these individuals face an additional risk: Heart disease. 

A recent study has shown that some breast cancer treatments, such as Herceptin (trastuzumab), anthracyclines, radiation therapy, and aromatase inhibitors, may increase the risk of heart-related issues that can lead to heart failure in cancer patients. However, by understanding these risks, you can take steps to protect your heart while navigating your cancer journey.

What Can You Do To Protect Your Heart?

Understanding all your treatment options is the best way to protect your health. For example, HER2 targeted therapies can cause the heart muscle to weaken (leading to heart failure). But, for some women, the reduction in heart function is only temporary. Being able to weigh the different treatment options, their pros, and their cons can help you decide on the right treatment for you based on the potential complications. You have a right to make an informed decision. 

What Are Some Cancer Treatment Drugs That Affect the Heart?

Here are a few treatments to be aware of:

• Anthracycline – Doxorubicin

Anthracycline is a chemotherapy drug known for cardiac toxicity. It can damage the heart to the point of causing chronic or life-threatening issues. If you receive this medication, you will need to have your heart monitored throughout treatment. As a side note, studies have suggested that administering this drug in smaller doses and across a longer period of time may reduce the risk of heart failure.

• Doxil

Doxil® is a drug that can help reduce side effects to the heart. It’s typically used alongside chemotherapy, specifically with doxorubicin. 

• Herceptin (trastuzumab)

This cancer medication targets HER2. It is used for early-stage breast cancer and is FDA approved, but it has the potential to damage the heart muscle. 

Does Radiation Lead to an Increased Risk of Heart Disease?

Radiation therapy may slightly increase the risk of heart disease over time, but the overall risk remains relatively low. A study in The New England Journal of Medicine found that while radiation exposure increases the chance of a heart event, the overall percentage remains small. 

For example, if a healthy woman’s risk of ischemic heart disease is 1.9%, it would rise to 2.4% after receiving three units of radiation.

While there’s currently no guaranteed way to prevent heart-related side effects from breast cancer treatment, researchers are making exciting progress in developing new, safer therapies. 

And, with continued medical advancements, personalized treatment plans, and proactive heart care, survivors can live longer, healthier lives.

If you or a loved one are undergoing breast cancer treatment, talk to your doctor about ways to protect your heart. You have options, and with the right information, you can make the best choices for your long-term health and well-being.

What Is the Link Between Breast Cancer and Heart Disease?

In one study, it was determined that adult survivors of cancer had a 42% increased risk of cardiovascular disease compared to those who didn’t have cancer. This isn’t specific to breast cancer, but all cancers, due to the nature of chemotherapy, radiation, and related treatments. 

What Is the Risk of Cardiotoxicity in Breast Cancer Patients?

It depends on the treatment. The incidence of cardiotoxicity was noted as up to 34 percent when targeted agents and anthracycline were combined, according to research from 2023.

Does Radiation for Breast Cancer Damage the Heart?

It is possible for radiation for breast cancer to damage the heart and lungs. As a result of that damage, the risk of heart disease and lung cancer may increase. 

What Are Late Cardiac Effects of Cancer Treatment?

Some of the late cardiovascular complications from cancer therapy include heart failure, hypertension, cardiomyopathy, and arrhythmia. 

Dr. Charles Weaver, Medical Advisor for Learn Look Locate and Medical Oncologist, has reviewed this article. 

Learn Look Locate is proud to present expert insights from Dr. Charles Weaver, founder of Cancer Connect and a key contributor to our mission at Learn Look Locate. Dr. Weaver’s expertise is an integral part of our joint newsletter with Cancer Connect, which has been empowering breast cancer patients for over a decade. The newsletter is distributed monthly to over 30,000 women who have opted in and will support them from diagnosis through treatment and survivorship. You can sign up for the newsletter by scrolling to the bottom of the page and submitting your email. 

Dr. Weaver’s involvement in Cancer First Calls and our Community Page reflects our commitment to providing comprehensive support and information to those affected by breast cancer. He continues to remain dedicated to the mission of educating and informing patients of their options. Read more about Dr. Weaver’s breast cancer insights here. 

If you have been diagnosed with breast cancer, you can schedule your Cancer First Call here.